Propolis, a Biological Resin with Healing Properties
DOI:
https://doi.org/10.46588/invurnus.v16i1.38Keywords:
Propolis, Cancer, Antiproliferative propiertiesAbstract
Propolis, along with honey, royal jelly, beeswax and bee venom, is a bee product that has drawn great attention due to its pharmacological properties. Propolis is a resinous substance made by bees from exudates, resins and latices secreted from leaves and leave buds of plants. It is a very complex biological matrix, with over 500 chemical constituents described to date. Propolis has different biological properties, anti-cancer activity being one of them. This article briefly describes the different types of bee products with a special focus on propolis and its chemical composition. Then, in the context of cancer biology, discusses the molecular events underlying the anti-cancer effects of propolis, identifying the key molecules involved. The effect of propolis on proliferation, cell cycle progression, apoptosis, migration of cancer cells and angiogenesis is reviewed. Propolis is a biological matrix with a great potential for isolation of chemicals with anti-cancer activity, which alone, or in combination, could represent an alternative for the development of new anti-cancer therapies.
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